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Hyperpigmentation

Posted by nancygllsc on June 10, 2015 at 12:50 AM Comments comments (0)

Hyperpigmentation

Source: Cosmeceuticals

"Dr. Loretta, one big challenge for me is treating people with hyperpigmentation. Some people come in after seeing many doctors and after years on protocols like Obagi or TCA peels, without ever clearing. Have you got advice on how to give confidence to clients that I can really help them?" JD, Miami, FL Dr. Loretta’s Answer….Here you go! Tips for Hyperpigmentation Management 1. FIND OUT WHY: Get a good history of ethnic background and any new products, medications, or procedures that the person uses or had been using during the onset of the hyperpigmentation or for the six months prior to onset. 2. BRING IN “THE BAG”: Many times these patients have used many things that could be a problem and they don’t realize it. Ask them to bring in a bag filled with all the products they use on their face and neck…this should include depilatories, fragrance they may spray on their necks, hair spray. Look for certain fragrances, like musk, which is notorious for staining skin; sodium lauryl sulfate, which can inflame skin and then cause pigmentation; and other possible irritants which could cause inflammation and/or photosensitivity. 3. EXAMINE THE SKIN: Along with the history, a good skin exam can help to finally resolve even longstanding hyperpigmentation. For instance, many people diagnosed with melasma really have post-inflammatory hyperpigmentation (PIH) instead. If the correct diagnosis is really PIH, you have to clear the inflammation before you can get rid of the hyperpigmentation. Examples would be people who are experiencing lingering stains after acne breakouts or laser hair removal that leaves hyperpigmentation on the face. If the diagnosis is really staining after acne, you have to give the client a good at-home acne management regimen before you can resolve the hyperpigmentation problem. If you have difficulty identifying the cause(s) of the problem you can take a photo and email it to us at [email protected] and we will help you!! 4. DAILY REPLENISHING SPF 36 IS A MUST: Daly Replenishing Sunblock SPF 36 (even if the person comes to you, as they often do, using SPF 80 or more!)…the Zinc in the formula will calm the skin which helps with management of hyperpigmentation. This is a product that all people with hyperpigmentations should use. 5. MANAGE MELANOGENESIS: The process that creates melanin (or pigment) in the skin can be triggered by both inflammation and hormones. There are numerous substances that help to reduce pigmentation in the whole process. Some of these tyrosinase-inhibiting ingredients include antioxidants such as Vitamin C (Ascorbic Acid) and Resorcinol (found in J-Peel). Our Ultra Benefits Moisturizer has broad-spectrum protection. Other ingredients that prove beneficial are retinol and 2% hydroquinone. Case presentation This woman had a two year history of hyperpigmentation that was diagnosed as melasma. She also complained of clogged pores and breakouts. She hadn’t responded to traditional regimens. Her before and after photos were taken 12 weeks apart. Here’s how she improved with products and peels: She was placed on the following at-home regimen: 1. Salicylic Face and Body Wash: (2% Salicylic Cleanser): since excess pigment gets stored for weeks in the dead cells of the stratum corneum, this helps to lessen hyperpigmentation - and you’ll note it helped her pore appearance as well (am/pm) 2. Dual Action Toner: to micro-exfoliate (am/pm) 3. Vita-Soothe: this anti-oxidant hydrating serum brightens skin as it moisturizes. Vita-Soothe recreates skin’s protective barrier function to protect against environmental insults and therefore aids in preventing new hyperpigmentation (am/pm) 4. Ultra Benefits: This twice-daily moisturizer with our proprietary ABF™ complex provides the only broad spectrum anti-oxidant coverage on the market, soy for skin lightening and three skin firming peptides (am/pm) 5. Daily Replenishing SPF 30+: This physical sunblock contains 7.5% Zinc Oxide and 2.4% Titanium Dioxide to not only effectively block pigment-producing UVA but also to calm skin (am only) In-Office Peels: She had a series of 70% CosMedical Glycolic Washes weekly or biweekly, depending on scheduling issues, for a total of six CosMedical peels. Other Important Information: She stopped her laser hair removal treatments since we determined that her real diagnosis was not melisma but PIH after laser hair removal; her hyperpigmentation coincided with the areas of laser hair removal which had been performed approximately three months prior to the onset of the hyperpigmentation. She continues to do well after the peels and is scheduled to have a maintenance peel every three months.

Skin Deep Beauty: The Importance of Adopting a Solid Skin Care Routine

Posted by nancygllsc on June 10, 2015 at 12:25 AM Comments comments (0)

Skin Deep Beauty: The Importance of Adopting a Solid Skin Care Routine

The human body is truly amazing, and perhaps one of the most amazing aspects of the human body is its skin. Human skin is the largest organ of the body, and serves as its first line of defense against the elements. Not only does it protect the body and its vital organs from infection and the outside world, it also regulates the body's temperature by producing sweat when hot and goosebumps when cold. In addition, it breathes to let toxins out and vital oxygen in. As such, adopting a proper and thorough skin care routine is of the utmost importance. Many people associate skin care with treating acne, reducing fine lines and wrinkles, or minimizing the appearance of scars. For example, acne is the most common skin disorder in the United States and affects an estimated 40 to 50 million individuals. In fact, almost 85% of all people are afflicted with acne at some point in their lives, most often on their face, chest, and back. In some instances, it can even cause scarring. However, while treating acne and other skin conditions is important, proper skin care isn't just about looking better, it's about protecting your body and your overall health. After all, beauty really does come from within, and when your body and skin are healthy, your natural beauty will radiate. While creating and maintaining a proper skin care routine involves several factors, such as diet, exercise, and drinking copious amounts of water, it also involves using professional skin care products, especially sunscreen. Even on a cloudy day, UV radiation from the sun reaches the earth's surface. Therefore, using sunscreen everyday can help to reduce the risk of developing skin cancer, as well as keep your skin looking young. Professional skin care products and professional cosmetic solutions for skin care are worth their weight in health! They contain the finest and most powerful ingredients to improve the condition of the skin, compared to their inexpensive drugstore counterparts. While high end private label cosmetics aren't always available at your neighborhood grocery store, they can be found in spas, doctor's offices, and select retailers. An added benefit to using professional skin care products is that the majority of private label skin care manufacturers do not participate in or condone animal testing, a fact which is becoming more and more important to many concerned and eco-conscious consumers.

Source: Cosmeceuticals 

Existing Depigmenting substances

Posted by nancygllsc on June 10, 2015 at 12:10 AM Comments comments (0)

They act through:

 

Tyrosinase Inhibition

Inhibitors of Inflammation-induced Melanogenic Response

Peroxidase inhibition

Product Reduction and ROS (Radical Oxygen Scavengers)

 

Tyrosinase inhibition

hydroquinone

4-hydroxyanisole

4-S-CAP and derivatives

Arbutin

Aloesin

Azelaic Acid

Kojic Acid

Ellagic Acid

Resveratrol

Oxyeresveratrol

Licorice Extract

Lactic Acid

 

Inhibitors of Inflammation Induced Melanogenic Response

 

Chamomille

Corticosteroids

Gliabridin

Tranexamic Acid

 

Peroxidase inhibition

 

Phenol/Catechols

Methimazole

Green Tea

Topical Indomethacin

 

Product Reduction and ROS (Radical Oxygen Scavengers)

 

Ascorbic Acid (Vitamin C)

a-Lipoic Acid

a-Tocopherol

Pycnogenol


source:

Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th Regional Conference of Dermatology (RCD) – Manila, Phillipines

Cysteamine Cream (CC): The evidence against hydroquinone and treatment of hyperpigmentation

Posted by nancygllsc on June 10, 2015 at 12:05 AM Comments comments (3)

Cysteamine Cream (CC): The evidence against hydroquinone and treatment of hyperpigmentation

 

Hydroquinone is the gold standard in the treatment of hyperpigmentary disorders but there are 3. things to bear in mind:

-a concentration of 4% or more is needed to be effective.

-because of a higher concecntration, side effects such as exogenous ochronosis are a risk. Because of a lack of evidence pertaining to long term toxicology issues, the substance is banned in Europe for use as an over-the-counter (OTC) drug.

-hydroquinone is a non-natural substance which is part of the phenol molecules. It is toxic to pigment cells (melanocytes) and its effects can be irreversible.

 

Cysteamine is a non melanocytoxic molecule comparable in this sense to others such as arbutin and kojic acid.

It has been known for its depigmeting effect for over 5 decades and in the early 2000’s in was shown by an Australian team of researchers to exert its effect by inhibiting tyrosinase, a key enzyme involved in the early phases of melanin synthesis.

The problem which is now solved with a new technology was that the molecule was unstable and malodorous when compiled in topical preparations

1. Hydroquinone 4% was compared with Cysteamine Cream (CC). 6 subjects were treated with Hydroquinone (HQ) on one ear and CC on the other. Another 6 were treated with the vehicle alone. Frequency of application: once daily for 10 days

-a considerable depigmentation is already visible to the naked eye.

-colorimetry shows that the degree of pigmentation is lower in CC than the vehicle. There is no staistically significant difference between CC and HQ.

-biopsies of the skin show similar results when the quantity of melanin is measured (spectrophotometric analysis)

 

2. 10 Individuals with dark skin (phototype IV – VI of Fitzpatrick) are treated every evening for 3 weeks.

A close up picture of the skin (dermoscopy) shows uniform depigmentation

Confirmation of visual results is done with colorimetry (statistically significant: p smaller than 0.05 according to student’s test)

 

3. 40 subjects with melasma are treated nightly for 6 weeks.

A close up picture of the skin (dermoscopy) shows uniform depigmentation

Confirmation of visual results is done with colorimetry (statistically significant: p smaller than 0.05 according to student’s test)

Irritation is observed in 2 patients which is reveresed when the treatment is stopped.

A notice to users: because of a dilation of blood vessels, a heat sensation may be felt upon applying the product the first time.

 

4. Depigmentation is also seen in the 35 patients treated for post-inflammatory hyperpigmentation (same treatment regimen as “3”).

However there is no comparison with the natural spontaneously favorable evolution of post inflammatatory hyperpigmentation.

 

5. To conclude Cysteamine Cream is effective, safe and user-friendly and can be considered a treatment option for the treatment of hyperpigmentary skin conditions.

 

adapted for the online version

 

Hsu C. Cysteamine Cream as a new depigmenting product. 9th Asian Dermatological Congress (ADC) 13 – Hong Kong, SAR

 

Related posts:

 

Cysteamine cream as a new skin depigmenting agent

Dermatology in Asians (For Professionals)

Melasma (Chloasma) (Pregnancy Mask) Diagnostic elements, epidemiology and importance of sunprotection

Tags: chloasma, Cysteamine cream, Cysteamine crème, dépigmentation, Hydroquinone, hyperpigmentation post-inflammatoire, melasma, postinflammatory hyperpigmention, skin whitening

 

source: http://www.globale-dermatologie.com/en/cysteamine-creme-cc-comparaison-avc-lhydroquinone-et-traitement-de-troubles-de-lhyperpigmentation-pour-les-professionnels.html#.VXcOIWBYjbo

 

Aromatherapy books

Posted by nancygllsc on August 18, 2013 at 5:30 AM Comments comments (4)

Reference Guide for Essential Oils, here I offer a link to some aromatherapy books. I hope you enjoy them as much as I do. 

let me know if you have any quiestions. 


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